A statement released by the star said: “We're not together anymore. It's very difficult and very personal, so we hope that our privacy is respected.”
Clooney, 50, is currently in London filming his new movie Gravity with Sandra Bullock.
GEORGE CLOONEY had been dating Canalis, 32, since 2009.
Earlier this month Canalis dismissed rumors in Italian weekly magazine Chi that the couple were splitting and seemed to suggest the couple might even wed.
She said: “I could never be with someone who every time he opens his mouth says he doesn't want a child with me or to marry me.”